Epidemiologi Penderita Tumor Ganas Kepala Leher di Departemen Telinga Hidung Tenggorokan - Kepala Leher Rumah Sakit Dr. Hasan Sadikin Bandung, Indonesia, Periode 2010–2014

Muhammad Syah Mirza Sabirin, Agung Dinasti Permana, Bogi Soeseno

Sari


Latar Belakang: Tumor ganas kepala leher adalah kanker yang berasal dari traktus aerodigestif bagian atas seperti traktus sinonasal, rongga mulut, faring dan laring. Tumor ganas kepala leher merupakan masalah kesehatan dengan mortalitas tinggi. Insidensinya meningkat dan menyerang berbagai individu. Penelitian bertujuan untuk mengetahui epidemiologi penderita tumor ganas kepala leher di Departemen Telinga Hidung Tenggorokan (THT-KL), Rumah Sakit Dr. Hasan Sadikin Bandung 2010–2014.Metode: Penelitian dilakukan secara deskriptif dari rekam medis penderita tumor ganas kepala leher di Departemen THT-KL, Rumah Sakit Dr. Hasan Sadikin Bandung periode 2010–2014, yang diambil secara total sampling.Hasil: Terdapat 1439 pasien penderita tumor ganas kepala leher. Sebanyak 1081 penderita diinklusi; 631 laki-laki dan 450 perempuan. Kebanyakan berpendidikan SD (44.2%), bekerja sebagai ibu rumah tangga (30.6%), dan berusia 46–55 tahun (28.7%). Tumor berlokasi di nasofaring (39.4%), sinonasal (16.9%), laring (13.7%), orofaring (6.4%), tiroid (6.1%), rongga mulut (3.5%), hipofaring (2.5%), dan kelenjar parotis (2.2%). Histopatologi terbanyak yaitu undifferentiated carcinoma (47.3%) dan karsinoma sel skuamosa (31.2%), dengan Stadium I (6.8%), II (13.3%), III (24.5%), IV (55.4%). Simpulan: Kasus tumor ganas kepala leher di departemen THT-KL adalah sebanyak 1439 orang, yang tertinggi adalah karsinoma nasofaring. Lebih banyak terjadi pada laki-laki, lanjut usia, berpendidikan SD, profesi ibu rumah tangga, penderita dengan stadium lanjut dan histopatologi undifferentiated carcinoma Saran: Perbaikan kelengkapan serta sistem penyimpanan data rekam medis. Prevensi, edukasi dan deteksi dini pada masyarakat umum mengenai tumor ganas kepala leher.

Kata Kunci: Epidemiologi, tumor ganas kepala leher


Introduction: Head and neck cancer is carcinoma that arises from upper aerodigestive tract such as sinonasal tract, oral cavity, pharynx, and larnyx. Head and neck cancer is a health problem with a high mortality rate which are increasing and effect many individuals from diverse backgrounds. Aims: Aim of this research is to ascertain the epidemiology of head and neck cancer patients at the Otorhinolaringology-Head and Neck Surgery Department, Dr. Hasan Sadikin General Hospital Bandung, Indonesia in 2010–2014 Methods: A descriptive method from medical records of head neck cancer patients at Department of Otorhinolaringology-Head and Neck Surgery, Dr. Hasan Sadikin General Hospital Bandung in 2010–2014 that used the total sampling method. Results and Discussion: There were 1,439 head and neck cancer patients in this research, 1081 were included, of them 631 were men and 450 were women. Most of them were elementary educated (44.2%), housewives (30.6%), and those aged 46–55 years old (28.7%). There were nasopharyngeal (39.4%), sinonasal (16.9%), larnyx (13.7%), oropharnyx (6.4%), thyroid gland (6.1%), oral cavity (3.5%), hypopharynx (2.5%), and parotid gland (2.2%) cancer. The major histopathological findings were undifferentiated carcinoma (47.3%) and squamous cell carcinoma (31.2%). Patients with stage I (6.8%), II (13.3%), III (24.5%), and IV (55.4%). Head neck cancer patients at the Otorhinolaringology-Head and Neck Surgery Department, Dr. Hasan Sadikin General Hospital Bandung are 1439 cases, with nasopharyngeal carcinoma cases being most predominant. There was a higher instance in middle aged and older, men, and elementary school educated. On the other hand, housewives were also highly affected. Patients came with advanced stages; undifferentiated carcinoma was the major histopathology
Keywords: Epidemiology, head and neck cancer


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Referensi


Ferreira M, Souza JAD, Cohen E. Role of molecular markers in the management of head and neck cancers. Curr Opin in Oncol. 2011;23(3):259–64.

Syrigos KN, Karachalios D, Karapanagiotou EM, Nutting CM, Manolopoulos L, Harrington KJ. Head and neck cancer in the elderly: An overview on the treatment modalities. Cancer Treat Rev. 2009;35(3):237–45.

Goon PK, Stanley MA, Ebmeyer Jr, Steinsträsser L, Upile T, Jerjes W, et al. HPV & head and neck cancer: a descriptive update. Head Neck Oncol. 2009;1:36.

Hassan MA, Lund VJ, Howard DJ, Sacker AA. Are the demographics for squamous cell cancer in the head and neck changing in the United Kingdom? J Laryngol Otol. 2007;121(2):154–7.

Haddad RI, Shin DM. Recent Advances in Head and Neck Cancer. N Engl J Med. 2008;359(11):1143–54.

Kim L, King T, Agulnik M. Head and Neck Cancer: Changing Epidemiology and Public Health Implications. Oncology. 2010; 24(10): 915–9.

Alvarenga LdM, Ruiz MT, Bertelli ECO, Ruback MJC, Maniglia JV, al. e. Epidemiologic evaluation of head and neck patients in a university hospital of Northwestern São Paulo State. Braz J Otorhinolaryngol. 2008;74(1):68–73.

Chaukar DA, Walvekar RR, Das AK, Deshpande MS, Pai PS, Chaturvedi P, et al. Quality of life in head and neck cancer survivors: a cross-sectional survey. Am J Otolaryngol. 2009;30(3):265– 70.

Deschler DG, Day T, editors. Pocket guide to neck dissection classification and tnm staging of head and neck cancer and neck dissection classification. 3rd Edition. Alexandria: American Academy of Otolaryngology-Head and Neck Surgery Foundation, Inc.; 2008. p. 16–28

WHO. Pathology and Genetics of Head and Neck Tumours. Lyon: IARC Press; 2005.

Dorland's Pocket Medical Dictionary. 28th ed. Philadelphia: W.B. Saunders; 2009. Tumor; p. 875–6.

Dahlstrom KR, Little JA, Zafereo ME, Lung M, Wei Q, Sturgis EM. Squamous cell carcinoma of the head and neck in never smoker–never drinkers: a descriptive epidemiologic study. Head Neck. 2008;30:75–84

Munir M. Keganasan di bidang telinga hidung tenggorok. In: Soepardi EA, Iskandar N, Bashiruddin J, Restuti RD, editors. Buku ajar ilmu kesehatan telinga hidung tenggorok kepala & leher. 6th ed. Jakarta: Balai Penerbit FKUI; 2007. p. 132

Lutzky VP, Moss DJ, Chin D, Coman WB, Parsons PG, Boyle GM. Biomarkers for cancers of the head and neck. Clin Med Insights Ear Nose Throat. 2008;1:5–15.

Hashibe M, Brennan P, Chuang S-c, Boccia S, Castellsague X, Chen C, et al. Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the international head and neck cancer epidemiology consortium. Cancer Epidemiol Biomarkers Prev. 2009;18(2):541–50.

Durazzo MD, Araujo CENd, Neto JdSBo, Potenza AdS, Pedro Costa FvT, Bianchi C, et al. Clinical and epidemiological features of oral cancer in a medical school teaching hospital from 1994 to 2002: increasing incidence in women, predominance of advanced local disease, and low incidence of neck metastases. Clinics (Sao Paulo). 2005;60(4):293–8.

Tawfik HM, El-Maqsoud NMRA, Hak BHAA, El-Sherbiny YM. Head and neck squamous cell carcinoma: mismatch repair immunohistochemistry and promoter hypermethylation of hMLH1 gene. Am J Otolaryngol. 2010;32(6):528–36.

Powles T, Powles J, Nelson M, Sandison A, Peston D. Head and neck cancer in patients with human immunodeficiency virus infection: incidence, outcome and association with Epstein-Barr virus. J Laryngol Otol. 2004;118(3):207–12.

Ruback McJC, Galbiatti ALv, Arantes LMRB, Marucci GH, RussoI A, Ruiz-CintraII MT, et al. Clinical and epidemiological characteristics of patients in the head and neck surgery department of a university hospital. Rev Assoc Med Bras. 2012;130(5):307–13.

Santos LC, Cangussu MC, Batista Ode M, Santos JP. Oral cancer: Population sample of the State of Alagoas at a Reference Hospital. Braz J Otorhinolaryngol. 2009;75(4):524–9.


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